theo macmillan

Sunday, June 10, 2012

Bus drivers threaten strike over Games pay

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Saturday, June 9, 2012

MILITARY AIRCRAFT B-1 VECTOR.eps

Stock Vectors

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Las Vegas Setting Rumored for Hangover 3

The Hangover 3 Tijuana Mexico

Call it taking the long way around, but it seems as though the rumors that The Hangover 2?would be in Mexico were just a little bit too?clairvoyant. Hangover 2?was set in Thailand ? but The Hangover 3?will be in Mexico. Tijuana, to be exact.

However, it seems that Mexico will only be a pit stop: scroll down for the full scoop on where infamous Wolf Pack ? Ed Helms, Bradley Cooper and Zach Galifianakis ? could be headed on their next misadventure.

It has long been said that the Wolfpack will do a bit of party-hopping in their next installment.?Bradley Cooper recently stated that the film would shoot in LA, while?The Toronto Sun?mentions the new Tijuana location. In addition to Mexico, the Sun also makes brief mention of Las Vegas, which (if true) would return the Wolfpack to the scene of their first crimes against partying.

Right now these reports are coming from ?sources close to the film,? so they must be taken with the obligatory grain of salt. However, early on, word was that The Hangover 3 story would be different from its predecessors.?Rumor went so far as to suggest that the story could involve ? at one point or another ? the Wolfpack having to break free of a mental institution where Alan (Galifianakis) ends up being committed. No idea if that will turn out to be the actual plot ? but the ?Pack being on the lamb could explain the Mexico location. A third Mike Tyson cameo could also explain a stop in Vegas. Just some theories.

Hell, the mere news that there will be different locations in the film is welcome news for those of us who weren?t very impressed with the repetitious nature of?The Hangover 2. Some kind of variation of the formula is clearly needed, and it?ll be interesting to see what director Todd Philips comes up with. Be warned: we asked for something different, and there?s no telling how wild the curveball Phillips throws at us will be.

Source:??Toronto Sun?(via?The Film Stage)

"Follow us if you want to live."

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Immune system 'circuitry' that kills malaria in mosquitoes identified

Friday, June 8, 2012

Researchers at the Johns Hopkins Malaria Research Institute have, for the first time, determined the function of a series proteins within the mosquito that transduce a signal that enables the mosquito to fight off infection from the parasite that causes malaria in humans. Together, these proteins are known as immune deficiency (Imd) pathway signal transducing factors, are analogous to an electrical circuit. As each factor is switched on or off it triggers or inhibits the next, finally leading to the launch of an immune response against the malaria parasite. The study was published June 7 in the journal PLoS Pathogens.

The latest study builds upon earlier work of the research team, in which they found that silencing one gene of this circuit, Caspar, activated Rel2, an Imd pathway transcription factor of the Anopheles gambiae mosquito. The activation of Rel2 turns on the effectors TEP1, APL1 and FBN9 that kill malaria-causing parasites in the mosquito's gut. More significantly, this study discovered the Imd pathway signal transducing factors and effectors that will mediate a successful reduction of parasite infection at their early ookinete stage, as well as in the later oocyst stage when the levels of infection were similar to those found in nature.

"Identifying and understanding how all of the players work is crucial for manipulating the Imd pathway as an invention to control malaria. We now know which genes can be manipulated through genetic engineering to create a malaria resistant mosquito" said George Dimopoulos PhD, professor in the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health.

To conduct the study, Dimopoulos's team used a RNA interference method to "knock down" the genes of the Imd pathway. As the components were inactivated, the researchers could observe how the mosquito's resistance to parasite infection would change.

"Imagine a string of Christmas lights or other circuit that will not work when parts aren't aligned in the right sequence. That is how we are working with the mosquito's immune system," explained Dimopolous. "We manipulate the molecular components of the mosquito's immune system to identify the parts necessary to kill the malaria parasites."

Malaria kills more than 800,000 people worldwide each year. Many are children.

###

Johns Hopkins University Bloomberg School of Public Health: http://www.jhsph.edu

Thanks to Johns Hopkins University Bloomberg School of Public Health for this article.

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