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Fortunately, my former classmate referred me to the website of a Banner Creator. He said that the good quality of the banner ads of his online hardware store has helped made his business successful. More and more people order from his online store since he started using these banners. According to him, the website guarantees a pixel perfect design for their Banner Designing Servicethat makes the ad more attractive to visitors. When I checked out the website, I found samples in their portfolio. These ads really look interesting and I knew that very moment that it was what I needed to boost my business. They were good in combining colors that make the banners attention-grabbing. I decided to try them myself for my own website. I noticed the difference before and after utilizing those ads. I gained new costumers who told me that they became more aware about my site and my products because of my striking banner ads.
Without my former classmate?s suggestion, my website would have remained boring and dull. I am grateful that he shared with me one of the factors that made him a successful entrepreneur, which is the website.
TOKYO (Reuters) - Asian shares fell on Thursday as weak euro zone data, a sluggish debt auction in Italy and fears of a potential run on Cyprus's banks stoked investors' concerns about instability in Europe.
European markets were seen subdued, with financial spreadbetters predicting London's FTSE 100, Paris's CAC-40 and Frankfurt's DAX to open down as much as 0.3 percent.
Benchmark indices in Spain and Italy were likely to open flat and 0.3 percent lower respectively.
A 0.4 percent fall in U.S. stock futures pointed to a weak Wall Street start.
Japan's Nikkei stock average closed down 1.3 percent, as euro zone worries prompted profit taking in exporters and financials.
The negative tone for Asian equities was compounded by the latest restrictive move by China, with its banking watchdog ordering banks to strengthen checks on the underlying assets of a range of wealth management products to ward off potential risks to the financial system.
The MSCI's broadest index of Asia-Pacific shares outside Japan fell 0.7 percent, wiping out the previous day's gains, which had taken the index to a one-week high.
Thursday is the last trading day for the first quarter for many Asian markets, which will be closed on Friday for the Good Friday holiday.
The pan-Asian index was set for its smallest quarterly gain since the second quarter last year with a 0.9 percent rise, which would also be its worst first quarter in four years.
"Multiple factors are denting sentiment, with uncertainties over the future of Cyprus despite the bailout, Italian political instability and bad economic indicators from the euro zone," said Hirokazu Yuihama, a senior strategist at Daiwa Securities in Tokyo.
Despite their recent retracement, Asian shares outside of Japan have generally stayed in a range for the first three months of 2013, holding near the upper end close to their highest levels since August 2011, as improving U.S. economic growth and hopes China will stay on a recovery track helped boost investors' risk appetite.
"China's move to tighten property regulations has been the biggest drag for Asia. Looking ahead, whether China can keep recovering will be the main issue speficic to this region," Yuihama said, adding that Southeast Asian markets may be exposed to the biggest adjustments if negative news spurred broader selling.
China shares, by far the worst regional performer on Thursday, were headed for their worst loss in nearly a month, hurting Hong Kong markets, with banks taking a hit after they were ordered to tighten control over wealth management products (WMP) and improve transparency.
Hong Kong shares slid 1.3 percent and Shanghai shares slumped 2.7 percent.
"The timing of the announcement caught the market by surprise, although people were already expecting the regulators to act," said Hong Hao, chief strategist at Bank of Communication International Securities.
Trading slowed generally as market players closed positions ahead of the Easter holidays.
"Whatever is happening in Europe in terms of Cyprus and the ramifications of that, maybe a lot of traders just don't want to be long or don't want to have positions over this long weekend," said Winston Sammut, investment director at Maxim Asset Management.
EURO VULNERABLE
Cypriots are expected to besiege lenders in the morning as banks reopen for the first time in almost two weeks.
Authorities imposed restrictions on cash withdrawals and may curb the use of credit cards abroad to keep a rein on money flows after the country agreed to a bailout deal that will wipe out some senior bank bondholders and impose losses on large depositors.
In Italy, the government's cost of borrowing over five years rose to its highest since October at an auction on Wednesday, reflecting investor wariness over a lack of progress in forming a new government and worries about Cyprus's bailout.
Meanwhile, data on Wednesday showed confidence in the euro zone economy fell more than expected in March after four straight months of gains.
"Headline risks for the euro should persist, although a positive turn of events in either country would probably come as a greater surprise given the market's subdued expectations," said Vassili Serebriakov, strategist at BNP Paribas.
The euro was at $1.2789 (8448 pence), hovering near a four-month low of $1.2750 (842 pence) touched on Wednesday.
The dollar was down 0.1 percent but still near Wednesday's 7-1/2-month peak of 83.302 against a basket of key currencies.
Fears about the euro zone underpinned safe-haven U.S. Treasuries and gold, while 10-year Japanese government bond yields fell to 0.510 percent, the lowest level since June 2003, on expectations strong stimulus measures will be announced by the Bank of Japan next week at its first policy meeting under new leadership.
Such anticipations drove the BOJ's benchmark interest rate down on Wednesday to 0.059 percent, the lowest since July 13, 2006, which was one day before the central bank ended its policy to keep the overnight call rate effectively at zero percent.
U.S. crude futures rose 0.2 percent to $96.77 (63.93 pounds) a barrel while Brent added 0.3 percent to $110 (72.66 pounds).
London copper eased 0.2 percent to $7,590.50 (5,014.20 pounds) a tonne, with prices set to end the month and quarter down due to a lack of robust Chinese demand.
(Additional reporting by Clement Tan in Hong Kong, Ian Chua and Maggie Lu Yueyang; in Sydney; Editing by Eric Meijer & Kim Coghill)
Android 4.2.2 "Jelly Bean" is Google's latest refinement of what is now the world's most popular OS on new smartphones. For now, you can only get Android 4.2.2 on a few devices, including the?Google Nexus 4 phone, and the Google Nexus 7 and Nexus 10 tablets. It's also rolling out to existing Galaxy Nexus owners, and the newly announced Samsung Galaxy S4 will have it at launch. There's nothing revolutionary about Android 4.2.2, but there are enough significant updates to cement Jelly Bean's Editors' Choice status for mobile smartphone operating systems.
User Interface Improvements For this review, I tested Android 4.2.2 on a Google Nexus 4. As was the case with Android 4.1, the setup process is smooth, and faster than it is with earlier Android phones. Most of the default options were already checked, for example, and I had no problem adding my existing Google account. Once you're in, the OS walks you along with a series of translucent tip screens that appear over the home screen and main menu. This hand-holding is definitely helpful if you're new to the OS, though experienced users will already know many of the tips.
As we found when first testing Android 4.1, there's more going on here than just minor UI refinements. At Google I/O last year, Google engineering director David Burke talked about Project Butter, which was the company's effort to improve Android performance enough that it feels "buttery" smooth in use. This effort affected many aspects of the OS, such as improved vsync timing for faster frame rates on the display itself, triple graphics buffering for preventing dropped frames in video games, and improved overall touch-screen response.
In practice, there's definitely a noticeable improvement over, say, Android 4.0 "Ice Cream Sandwich." You can easily resize and move around icons and widgets on each home screen panel or delete apps by swiping the icon up, which causes it to disappear. The system font ("Roboto") already looked sharp and smooth before, and still does. But menu animations, finger swipes, and scrolling feel at least as solid as they do on iOS, if not better.
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Keyboard, Web Browser, and Messaging The predictive keyboard works well. I spent quite some time typing on it, and it seemed to do a much better job than before at guessing the word I meant, even whenever I typed several letters incorrectly. The prediction function works just as it does on Apple iOS 6.1, in that it can figure out what word you want to type even if your fingers are not hitting the on-screen keys directly, just by the grammar of your sentence and the built-in dictionary.
For the Swype-inclined, the new?Gesture Typing feature attempts to mimic Swype, in that you can now draw out words by gliding your fingertip over each letter on the on-screen keyboard. Google also boosted the predictive text engine to allow for spaces between words, as well as boosting the dictionary the engine uses overall, both for voice dictation and typing.
In fact, Android 4.2.2's predictive text engine also tops that of iOS, in that it still shows the bar beneath the text window with possible alternatives?rather than just one the way the iPhone does?and then pops it in with a little animated fade as you continue typing. These are small details, but they're beautiful in action. This is exactly the kind of polish Android needed all along, though the new BlackBerry Z10 on-screen keyboard has turned out to be even better.
The Web browser offers smooth handling of multiple tabs, which you can swipe among on a separate screen. One issue; while auto-rotate is switched off by default, when I turned it on, I noticed some pages had trouble formatting columns of text when flipping between landscape and portrait mode. In other words, the screen would be formatted correctly in one orientation, but then end up with a thin column and lots of white space in the other.
Adobe has officially dropped support for Flash starting with Jelly Bean 4.1. This doesn't bother me as much as it irks others. Even when it works on mobile devices, it doesn't really work all that well. The end of Flash for Android is hardly a surprise, at any rate, as Adobe said months ago it was discontinuing all mobile Flash development.
In the messaging app, tap the new message icon, and it pops up names and photos from your contact list as you type letters, including alternate phone numbers indented slightly as compared with the main one. I tested this function with a book of about 1,500 contacts and it was super fast.
Abou Zeid confirmed dead: France now says DNA tests confirmed that Abou Zeid, one of al Qaeda's most feared commanders in Africa, was the identity of the man killed by a French-led offensive in Mali.
By Lionel Laurent and Elizabeth Pineau,?Reuters / March 23, 2013
French soldiers patrol in northern Mali. France's Presidential office on Saturday March 23, 2013 said that DNA testing has shown that Al Qaeda-linked North African warlord Abou Zeid was killed in combat with French troops in Mali in February.
(AP Photo/Arnaud Roine/ECPAD, file)
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France confirmed "with certainty" on Saturday that Abdelhamid Abou Zeid, one of al Qaeda's most feared commanders in Africa, had been killed in Mali last month in a French-led offensive.
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The death of Abou Zeid, who raised millions of dollars kidnapping Western hostages, marks a heavy blow to al Qaeda's North African wing AQIM and to Islamist rebels battling French-led forces in northern Mali's Adrar des Ifoghas mountains.
The death of the ruthless commander - the trusted lieutenant of AQIM's elusive leader Abdelmalek Droukdel - was a major victory in France's nine-week-old campaign to drive al Qaeda-linked Islamists from Mali's desert north.
It raises questions, however, about the fate of several French hostages believed to be held by Abou Zeid's branch of AQIM.
"The president of the French Republic confirms with certainty the death of Abdelhamid Abou Zeid after an offensive by the French army in the Adrar des Ifoghas," the Elysee presidential palace said.
Previously France had said only that Abou Zeid was "probably" dead. Chad, whose troops are fighting alongside French forces in the Adrar des Ifoghas, announced in early March that the Algerian smuggler-turned-Islamist had been killed.
France had been awaiting the results of DNA testing - which finally confirmed Zeid's identity - before making an official announcement, a diplomatic source told Reuters.
French forces launched a ground and air campaign in Mali on Jan. 11, warning that the Islamist enclave in northern Mali controlled by AQIM and its allies presented a threat to international security.
The Islamists had hijacked a Tuareg rebellion which had driven Mali's demoralised army from the northern two-thirds of the landlocked country in April last year.
While the French-led offensive has pushed Islamists out of northern towns and remote mountain bases, militants have hit back with several suicide bombings in government-held areas.
A spokesman for AQIM said earlier this week it had beheaded a French hostage in retaliation for Paris' intervention, Mauritania's ANI news agency reported - a worrying development for France and its 14 hostages held in West Africa.
Abou Zeid is believed to have killed British hostage Edwin Dyer in 2009 and 78-year-old Frenchman Michel Germaneau in 2010. Confirmation of his death will turn attention to the fate of fellow al Qaeda commander Mokhtar Belmokhtar, who was also reported dead by Chad.
Saturday's statement made no mention of Belmokhtar, the mastermind of a mass hostage-taking in January at the In Amenas gas plant in the Algerian desert in which around 60 people were killed.
Edouard Guillaud, the head of France's joint chiefs of staff, said this month he was "extremely cautious" about reports of Belmokhtar's death, noting that some militant websites had said the al Qaeda commander, nicknamed 'the uncatchable', was still at large.
(Reporting by Lionel Laurent and Elizabeth Pineau; Editing by Daniel Flynn and Stephen Powell)
CHICAGO (AP) - A young Lebanese immigrant awaiting sentencing for placing a backpack he thought held a bomb near Chicago's Wrigley Field wrote a letter to the judge saying he drank "all day, every day" for months before the would-be attack.
In a seven page letter to U.S. District Judge Robert Gettleman, Sami Samir Hassoun apologizes and insists he has worked hard at becoming a better person, including by taking yoga instruction in jail.
The letter was included in a defense filing this week. Hassoun, in custody since his 2010 arrest, is scheduled to be sentenced April 5.
Prosecutors want a 30-year prison sentence for the 25-year-old, who pleaded guilty to weapons charges last year. The defense filing argues Hassoun deserves no more than 20 years, in part because they contend he was egged on by an FBI informant to concoct the bombing scheme.
In his plea agreement, Hassoun admitted he dropped what he believed was a bomb into a trash bin on a crowded street by the Chicago Cubs' stadium in 2010. The fake device was given to him by undercover FBI agents who had been tipped off by the informant.
In the letter - dated Oct. 12, 2012, but released publicly this week - Hassoun tells Gettleman, "I am so ashamed of my actions and of this horrific crime that I've committed."
He describes feeling despondent and confused with his new life as a bakery worker, frustrated by broken dreams of becoming rich after he and his parents moved to the U.S. from Lebanon in 2008.
"By two to three months before my crime, I was drinking all day, every day," he wrote. "I would open a bottle of Johnnie Walker Black in the morning and finish it by evening, while also drinking vodka and beer."
He smoked marijuana regularly and sometimes used cocaine and ecstasy, he wrote.
Hassoun said he has confronted his self-destructiveness, has taken anger-management courses and is working toward a degree through a University of Ohio program designed for inmates.
Hassoun, who was born in Beruit, blamed what he described as longstanding emotional issues, in part, on trauma that lingered with him since childhood living in Ivory Coast when bloody civil strife broke out in that African nation.
"I witnessed all these horrific and barbaric scenes and images from the balcony of our apartment," he wrote. "I lived in constant fear, hearing rumors that they were invading homes, and raping women and kids."
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Follow Michael Tarm at www.twitter.com/mtarm
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
ATLANTA (Reuters) - An Idaho man accused of slapping a child and using a racial slur on an airplane pleaded not guilty to federal assault charges in Atlanta on Wednesday, his lawyer said.
Joe Rickey Hundley of Hayden, Idaho, is accused of striking a 19-month-old boy in the face on board a Delta Air Lines flight on February 8, according to documents filed in U.S. District Court in Atlanta.
The boy's mother, who was seated with her son, said in interviews that the child was crying as the plane from Minneapolis descended into Atlanta.
An attorney for Hundley, 60, said he used a racial slur when the child started crying because of ear pressure, but she denied that Hundley struck the boy.
The baby is black and his adoptive mother, Jessica Bennett of Minneapolis, is white. Hundley also is white.
In a statement on Wednesday, Hundley's lawyer said he had been traveling to Atlanta to decide whether to remove his son from life support. Twenty-four hours before the flight, Hundley was told his son had overdosed on insulin and was "in a coma for life," attorney Marcia Shein said.
"On the flight, he was in distress, upset and grieving," Shein said.
In media interviews, the child's mother has said Hundley was belligerent and seemed intoxicated during the flight.
Hundley was fired from his executive position at AGC Aerospace & Defense after the alleged slapping incident, his attorney said. The Oklahoma City-based military technology company issued a statement describing the executive's behavior as "offensive and disturbing."
Hundley's son, whose age was not given, died the day after the flight, Shein said.
Hundley "has paid a terrible price for his hurtful words," the lawyer said.
Contact: Bernhard Hovemann Bernhard.Hovemann@rub.de 49-234-322-4235 Ruhr-University Bochum
How Drosophila recovers the neurotransmitter histamine
Bochum, 18.3.2013
In the fruit fly Drosophila, the functions of the three enzymes Tan, Ebony and Black are closely intertwined - among other things they are involved in neurotransmitter recycling for the visual process. RUB researchers from the Department of Biochemistry showed for the first time that flies cannot see without this recycling. Their analysis of the enzyme Black also raises new questions as to its function. Anna Ziegler, Florian Brsselbach and Bernhard Hovemann report in the Journal of Comparative Neurology", which chose this topic as cover story.
Tan, Ebony and Black are important for the visual process and the formation of the cuticle
The fruit fly's genes tan, ebony and black contain the construction plans for three enzymes with the same names that work together in hardening the outer shell of the body, the cuticle. The same enzymes also occur in the compound eye of the fly. Researchers therefore assume that Tan, Ebony and Black work together in vision - similar to the way they do in the formation of the cuticle. In fact, flies with mutations of the ebony and tan genes cannot see. A mutation of the black gene, however, has no such effect. Prof. Hovemann's team examined where the enzyme Black appears in the compound eye and the role it plays in vision.
Black and Ebony always occur together
First, the scientists tested where the genes ebony and black are active in the compound eye of the fruit fly and in its extra eyes on the head, the ocelli. They put different types of light-sensitive cells called photoreceptors, under the microscope. The result: both genes are always read together - just like in the cuticle. This suggests that the functions of the enzymes Ebony and Black are closely linked.
Vision requires a continuous flow of the neurotransmitter histamine
When light falls into the compound eye, the photoreceptors release the neurotransmitter histamine. In previous studies, Bochum's biochemists already demonstrated that histamine is recycled via the glial cells surrounding the photoreceptors. There, the enzyme Ebony inactivates the neurotransmitter histamine by binding it to the amino acid -alanine, thus creating -alanyl-histamine. This molecule is transported from the glial cells back into the photoreceptors. Here, -alanine is split off again by the enzyme Tan, and histamine is produced. Previously, it was assumed that the enzyme Black is responsible for producing the -alanine, which is required for the inactivation of histamine. However, if a fly's eye has no functional Black, the visual process still runs normally. Hovemann's team therefore looked into the question of whether there is another supply route for -alanine. They also tested whether the fly eye can get around the recycling of histamine; this would be possible if the photoreceptors could directly reabsorb the released neurotransmitter, without it being inactivated in the glial cells.
No functioning sense of sight without histamine recycling
The researchers examined flies that were neither able to produce histamine themselves nor recycle it, because they lacked the enzyme for histamine synthesis and the enzyme Ebony. The team measured the flies' vision using so-termed electroretinography, which not only shows the excitation of the photoreceptor cells, but also the transmission of the signal to the brain. Even when the researchers added histamine from outside, the flies were blind. With this test, they showed for the first time that, for vision, Drosophila is dependent on the histamine recycling in the glial cells. Without recycling the enzyme Ebony, the cells in the insect eye cannot make any use of the neurotransmitter.
Flies can also see with disturbed -alanine production
Cells are not only able to produce -alanine with the aid of the enzyme Black, but also by converting the molecule uracil into -alanine using other enzymes. Hovemann's team inactivated both production pathways for -alanine and tested the vision of the fruit fly again. According to the electroretinogram, the animals' sense of sight was not impaired by the double mutation. "The results seem to represent a contradiction", says Bernhard Hovemann. "Although the insect eyes with the double mutation cannot produce -alanine, the animals seem to have normal vision. At the same time, our data clearly shows that the recycling by attaching -alanine is necessary for the animals to see." The researchers suggest that -alanine like histamine is recycled in a circuit between glial cells and photoreceptors. This would mean that the enzyme Black merely compensates for -alanine losses. "That would explain why we do not immediately find visual defects in flies which cannot produce new -alanine", says Hovemann. These puzzles can, however, only be solved by further studies.
###
Bibliographic record
A.B. Ziegler, F. Brsselbach, B.T. Hovemann (2013): Activity and coexpression of Drosophila black with ebony in fly optic lobes reveals putative cooperative tasks in vision that evade electroretinographic detection, Journal of Comparative Neurology, DOI: 10.1002/cne.23247
Images online
Images related to this press release can be found online at: http://aktuell.ruhr-uni-bochum.de/pm2013/pm00078.html.en
Further information
Prof. Dr. Bernhard Hovemann
Work Group for Molecular Cell Biochemistry
Faculty of Chemistry and Biochemistry at the Ruhr-Universitt
44780 Bochum, Germany
Editor: Dr. Julia Weiler
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Bernhard Hovemann Bernhard.Hovemann@rub.de 49-234-322-4235 Ruhr-University Bochum
How Drosophila recovers the neurotransmitter histamine
Bochum, 18.3.2013
In the fruit fly Drosophila, the functions of the three enzymes Tan, Ebony and Black are closely intertwined - among other things they are involved in neurotransmitter recycling for the visual process. RUB researchers from the Department of Biochemistry showed for the first time that flies cannot see without this recycling. Their analysis of the enzyme Black also raises new questions as to its function. Anna Ziegler, Florian Brsselbach and Bernhard Hovemann report in the Journal of Comparative Neurology", which chose this topic as cover story.
Tan, Ebony and Black are important for the visual process and the formation of the cuticle
The fruit fly's genes tan, ebony and black contain the construction plans for three enzymes with the same names that work together in hardening the outer shell of the body, the cuticle. The same enzymes also occur in the compound eye of the fly. Researchers therefore assume that Tan, Ebony and Black work together in vision - similar to the way they do in the formation of the cuticle. In fact, flies with mutations of the ebony and tan genes cannot see. A mutation of the black gene, however, has no such effect. Prof. Hovemann's team examined where the enzyme Black appears in the compound eye and the role it plays in vision.
Black and Ebony always occur together
First, the scientists tested where the genes ebony and black are active in the compound eye of the fruit fly and in its extra eyes on the head, the ocelli. They put different types of light-sensitive cells called photoreceptors, under the microscope. The result: both genes are always read together - just like in the cuticle. This suggests that the functions of the enzymes Ebony and Black are closely linked.
Vision requires a continuous flow of the neurotransmitter histamine
When light falls into the compound eye, the photoreceptors release the neurotransmitter histamine. In previous studies, Bochum's biochemists already demonstrated that histamine is recycled via the glial cells surrounding the photoreceptors. There, the enzyme Ebony inactivates the neurotransmitter histamine by binding it to the amino acid -alanine, thus creating -alanyl-histamine. This molecule is transported from the glial cells back into the photoreceptors. Here, -alanine is split off again by the enzyme Tan, and histamine is produced. Previously, it was assumed that the enzyme Black is responsible for producing the -alanine, which is required for the inactivation of histamine. However, if a fly's eye has no functional Black, the visual process still runs normally. Hovemann's team therefore looked into the question of whether there is another supply route for -alanine. They also tested whether the fly eye can get around the recycling of histamine; this would be possible if the photoreceptors could directly reabsorb the released neurotransmitter, without it being inactivated in the glial cells.
No functioning sense of sight without histamine recycling
The researchers examined flies that were neither able to produce histamine themselves nor recycle it, because they lacked the enzyme for histamine synthesis and the enzyme Ebony. The team measured the flies' vision using so-termed electroretinography, which not only shows the excitation of the photoreceptor cells, but also the transmission of the signal to the brain. Even when the researchers added histamine from outside, the flies were blind. With this test, they showed for the first time that, for vision, Drosophila is dependent on the histamine recycling in the glial cells. Without recycling the enzyme Ebony, the cells in the insect eye cannot make any use of the neurotransmitter.
Flies can also see with disturbed -alanine production
Cells are not only able to produce -alanine with the aid of the enzyme Black, but also by converting the molecule uracil into -alanine using other enzymes. Hovemann's team inactivated both production pathways for -alanine and tested the vision of the fruit fly again. According to the electroretinogram, the animals' sense of sight was not impaired by the double mutation. "The results seem to represent a contradiction", says Bernhard Hovemann. "Although the insect eyes with the double mutation cannot produce -alanine, the animals seem to have normal vision. At the same time, our data clearly shows that the recycling by attaching -alanine is necessary for the animals to see." The researchers suggest that -alanine like histamine is recycled in a circuit between glial cells and photoreceptors. This would mean that the enzyme Black merely compensates for -alanine losses. "That would explain why we do not immediately find visual defects in flies which cannot produce new -alanine", says Hovemann. These puzzles can, however, only be solved by further studies.
###
Bibliographic record
A.B. Ziegler, F. Brsselbach, B.T. Hovemann (2013): Activity and coexpression of Drosophila black with ebony in fly optic lobes reveals putative cooperative tasks in vision that evade electroretinographic detection, Journal of Comparative Neurology, DOI: 10.1002/cne.23247
Images online
Images related to this press release can be found online at: http://aktuell.ruhr-uni-bochum.de/pm2013/pm00078.html.en
Further information
Prof. Dr. Bernhard Hovemann
Work Group for Molecular Cell Biochemistry
Faculty of Chemistry and Biochemistry at the Ruhr-Universitt
44780 Bochum, Germany
Editor: Dr. Julia Weiler
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Came in late and missed the live festivities as Samsung took the wraps off of its new Galaxy S 4? No problem -- thanks to its livestream on YouTube, you can check out the unedited video stream right now in full, or just skip to your (least) favorite parts. There was a tapdancing kid, a host from a TV show you probably don't watch and a dancing group of bridesmaids. No, seriously, that happened. There was also a new phone, so check out our event hub if you want to get straight to the details, or strap in and experience it all in video form, embedded after the break.
Update: Samsung has posted the edited video on YouTube, so now you can just press play.
A University of Colorado Cancer study published this week in the journalCarcinogenesis shows that bitter melon juice restricts the ability of pancreatic cancer cells to metabolize glucose, thus cutting the cells' energy source and eventually killing them.
"Three years ago researchers showed the effect of bitter melon extract on breast cancer cells only in a Petri dish. This study goes much, much farther. We used the juice ? people especially in Asian countries are already consuming it in quantity. We show that it affects the glucose metabolism pathway to restrict energy and kill pancreatic cancer cells," says Rajesh Agarwal, PhD, co-program leader of Cancer Prevention and Control at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences.
Agarwal's interest came from connecting the dots of existing research in a novel way. See, diabetes tends to presage pancreatic cancer and bitter melon has been shown to effect type-II diabetes, and has been used for centuries against diabetes in the folk medicines of China and India. Following this line of thinking, Agarwal and colleagues wondered what would happen if they closed out the middle man of diabetes and directly explored the link between bitter melon and pancreatic cancer.
The result, Agarwal says, is, "Alteration in metabolic events in pancreatic cancer cells and an activation of the AMP-activated protein kinase, an enzyme that indicates low energy levels in the cells."
Perhaps not coincidentally, bitter melon also regulates insulin secretion by pancreatic beta cells. After studies in cell cultures, the group showed that mouse models of pancreatic cancer that were fed bitter melon juice were 60 percent less likely to develop the disease than controls.
"It's a very exciting finding," Agarwal says. "Many researchers are engineering new drugs to target cancer cells' ability to supply themselves with energy, and here we have a naturally-occurring compound that may do just that."
The Agarwal Lab is now applying for grants that will allow them to move the study of bitter melon into further chemoprevention trials in mouse models of pancreatic cancer.
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University of Colorado Denver: http://www.ucdenver.edu
Thanks to University of Colorado Denver for this article.
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Within our busy studio we spin many plates, selecting the most effective marketing communication tools to launch new products, promote a business or service or deliver a louder shout in the marketplace. Lots of clients are preparing for the new financial year (April) and with this comes the spend of a new marketing budget. Keep it simple, manageable and trackable is the key Hopefully our top 10 tips below will help you keep focused.
From bedrooms to pet care and everything in between Creative partner many businesses and can guide you through the periphery of marketing options. Our experience stretches across many industries from KBB ? kitchen, bedroom and bathrooms, to manufacturing, B2B, B2C, Vending machines and vet practices. We specialise in areas such as logo design, corporate identity, branding, web design, print design and also delve into many other areas such as exhibitions and reception display.
CARACAS (Reuters) - Venezuela has fired the starting gun in a highly charged election race likely to pit Hugo Chavez's preferred successor, acting President Nicolas Maduro, against centrist opposition leader Henrique Capriles.
The pair have until Monday to register their candidacy for the April 14 vote, which will determine whether Chavez's self-styled nationalist-socialist revolution will live on in the OPEC nation, home to the world's largest proven oil reserves.
Chavez died on Tuesday at age 58 after a two-year battle with cancer.
Former vice president Maduro, 50, a hulking one-time bus driver and union leader turned politician who echoes Chavez's anti-imperialist rhetoric, is seen winning the election comfortably, according to two recent polls.
He pushed a snap election to cash in on a wave of empathy triggered by Chavez's death, and was sworn in as acting president on Friday to the fury of Capriles.
The 40-year-old Miranda state governor, who lost to Chavez in October but garnered the oppositions' biggest vote against him, accused the government and Supreme Court of fraud for letting Maduro campaign without stepping down.
"It's terrible what they have done. They have violated the constitution repeatedly," said opposition supporter Beatriz Rueda, 62, who works in a Caracas travel agency.
"They have taken over all of the powers, the courts. ... The elections must be transparent. We don't want a confrontation. We don't want a civil war."
Maduro, who was sworn in as acting president in Congress on Friday and handed the red, yellow and blue presidential sash, has vowed to carry on where Chavez left off.
He has also adopted his mentor's touch for the theatrical, accusing imperialists, often a Chavez euphemism for the United States, of killing the charismatic but divisive leader by infecting him with cancer.
DEEP DIVIDE
Former paratrooper Chavez was immensely popular among Venezuela's poor for funneling vast oil wealth into social programs and handouts, but he railed against the wealthy and scared investors with nationalizations.
In heavily polarized Venezuela, some well-to-do even popped champagne corks to toast his death.
Capriles says, if elected, he would copy Brazil's "modern left" model of economic and social policies.
Venezuela's opposition coalition backed Capriles as its candidate on Saturday, and he is widely expected to formally accept the nomination.
"I am analyzing the declaration of the president of the national election commission and will tell the country about my decision in the coming hours," Capriles said on Twitter.
With candidates assigned a campaigning window of just 10 days, and at an immediate disadvantage given the state resources at Maduro's disposal, Capriles faces an uphill battle.
Some argue he has nothing to gain in running, but could also commit political suicide if he opts to sit out the race and effectively hand the presidency, and a raft of economic problems like sky-high inflation and a devalued currency, to Maduro.
The opposition rank-and-file is already heavily demoralized after losing last year's presidential race and taking a hammering in gubernatorial elections in December, stoking internal party divisions.
"There's no doubt that it's an uphill race for Capriles," said local political analyst Luis Vicente Leon. "Maduro is not Chavez. ... (But) the trouble is that given the race is so close to Chavez's death, emotions get inflamed and the candidate probably continues to be Chavez rather than Maduro.
"The big challenge for Capriles is not to campaign against Chavez but to try to take the fight to Maduro ... trying to show the huge gap (with Chavez) and relate it to the daily problems Venezuelans face."
With Chavez still looming large as his remains lie in state, already visited by several million people, that will be tough.
As with communist leaders Lenin, Stalin and Mao, Chavez's corpse is to be embalmed and put on display "for eternity".
"He liberated us from transnational companies and stood up to imperialist countries," Jose Vielma Mora, the governor of Tachira state, told Reuters. "We will be with Chavez forever."
(With reporting by Pablo Garibian, Ana Isabel Martinez, Deisy Buitrago, Marianna Buitrago, Patricia Velez and Enrique Andres Pretel; Editing by Andrew Cawthorne)
LONDON (Reuters) - World shares hit their highest level since June 2008 and the dollar touched a fresh 3-1/2-year high against the yen on Friday, ahead of U.S. jobs data expected to point to a continuing pick up in the world's biggest economy.
China also gave markets a boost as official data showed February exports grew 21.8 percent versus a year ago, more than double the expected rise.
European shares <.fteu3>, which have rebounded strongly after last week's Italian election and U.S. spending cuts-related wobble, were up 0.5 percent by mid-morning and on track for their biggest weekly gain since the start of the year.
Japan's Nikkei hit a 4-1/2 year high in Asian trading and 0.3, 0.7 and 0.5 rises by London's FTSE 100 <.ftse>, Paris's CAC-40 <.fchi> and Frankfurt's DAX <.gdaxi> helped MSCI's world share index <.miwd00000pus> to its highest level since late June 2008.
"There appears to be a strong risk-on mood in the market at the moment," said Ken Wattret, co head of European market economics at BNP Paribas.
"The negativity from the Italian elections was shrugged off pretty quickly, the Fed has made it clear that its policy will remain accommodative. If we get a get a good set of payrolls numbers, that will further fuel that sentiment."
Investors have been returning to stocks and other riskier assets over the last eight months as slowly improving world growth has been bolstered by the European Central Bank's pledge last August to prevent a break-up of the euro.
Friday's U.S. payrolls report, due at 8.30 a.m. ET is expected to show U.S. employers added 160,000 jobs last month, picking up slightly from January's 157,000 count.
It is key to gauging the Federal Reserve's policy course following the central bank's promise that as long as inflation doesn't pose a threat it will keep U.S. interest rates near-zero until unemployment falls to 6.5 percent.
DOLLAR STRENGTH
In the currency market, the sudden spike in tensions on the Korean peninsula added to the more dominant U.S. growth-led demand for the dollar <.dxy>.
Having said earlier in the week it was scrapping its armistice with South Korea, North Korea threatened the United States on Thursday with a preemptive nuclear strike after accusing it of warmongering.
The dollar <.dxy> was up 0.2 percent against a basket of major currencies but most of the focus was on its continued rise against the yen as it hit a 3-1/2 year high of 95.53 yen.
If the Bank of Japan's new leaders expands its stimulus program next month as expected, the dollar could trade in the 95-98 yen area or even open the way for a test of 100 yen, said Ronald Ip, Director of Wealth Solutions Group for HSBC Global Markets.
The euro, meanwhile, eased 0.1 percent, but clung to the bulk of the gains made the previous day, after the European Central Bank wrong-footed investors who had positioned for a more clear-cut signal on rate cuts from its head Mario Draghi.
Data from the euro zone continued to support the calls for a rate cut that some of the ECB's members had been pushing for at the bank's monthly meeting.
Although it was slightly better than had been expected, Spain's industrial output fell 5 percent year-on-year in January, the seventeenth month of declines. France's central bank also maintained its view that its economy will only just dodge recession in the first quarter of the year.
GRADUAL GAINS
With demand for low-risk assets cool ahead of the U.S. data, German Bund futures were little changed at 142.86 by mid-morning having fallen the previous day after the ECB's less dovish than expected tone.
Italian bonds continued to claw back the ground they lost after last week's inconclusive election result re-ignited concerns about its fiscal rehabilitation program.
The stronger dollar and the bright Chinese data were also the focus of commodity markets. Most of the world's raw materials are bought and sold in dollars so its movements can have a strong influence on prices.
Oil prices steadied above $111 a barrel, leaving them almost bang in line with where they started the year, while both copper and gold were little changed.
After a week which has seen five the world's top 10 central banks decide to leave policy unchanged in the face of a very modest global growth outlook, expectations for gradual gains in riskier assets are unchanged.
"We continue to look for ways to gradually build risk rather than reduce, and what we're seeing from the central banks leaves us unchanged in that view," Johan Jooste, chief market strategist at Merrill Lynch Wealth Management said.
"It's not like we're sittings on our hands. What we're doing is, at the margin, adding risk rather than piling straight into it at these levels."
(Additional reporting by Richard Hubbard; editing by Philippa Fletcher)
Real-time creative collaboration startup, Scoot & Doodle, which piggybacks on Google+'s Hangouts feature as the arena for its learn-through-play app aimed at middle school age through to college students, has closed a $2.25 million seed round. The investment comes from unnamed Silicon Valley angels and educational publishing giant Pearson.
Digital aids give toddlers an edge in Mandarin and other languages
The statistics supporting bilingual education are hard to argue with?improved problem-solving and social skills as well as higher test scores mean that foreign languages set kids up for success across the board. The sweet spot for second language acquisition comes early on, so exposure in the first few years is critical. While scouting this year's New York Toy Fair, we came across several innovative companies with targeted programming for toddlers, with many of them specifically targeting Mandarin. Here are four that provide both an educational and entertaining learning experience.
Chinese Cubes
A highly progressive program, ChineseCubes uses augmented reality to combine hands-on learning with dynamic feedback. Holding one of the cubes in hand, you'll notice Chinese characters, Roman type and QR codes printed on the sides. A webcam reads the code and provides animated and audio feedback to help along the learning process. Based on a core of 200 characters, the cubes combine to form more than 64,000 words and phrases.
Gordon & Li Li
Michele Wong McSween's board book series?named after her mom and dad Gordon & Li Li?was created to help the bilingual family's kids learn each other's language. A go-to source for kids to learn simple works in English and Mandarin, the beautifully illustrated book "Learn Animals in Mandarin" has also been converted to iPad, including fun exercises like finger-drawing Chinese characters on the screen. Keeping things focused on family, the voices for the app are provided by McSween's son and niece.
Early Lingo
Following the birth of her first child, Caryn Antonini developed Early Lingo as a way to incorporate the tenets of full immersion with at-home entertainment for children. The DVD-based program uses no translation and reflects Antonini's expertise in the subject as a graduate of Georgetown University School of Languages and Linguistics.
Little Pim
For very young learners, Little Pim provides easy learning through an array of DVDs, books and iOS apps?all based around the adventures of a panda. The program is available in numerous languages from Hebrew to Portuguese and focuses on providing young children with a core set of 360 words and phrases to use as a linguistic foundation.
Early Lingo image by James Thorne; All other images courtesy of the respective companies
Riot police clash with protesters in Port Said, Egypt, Tuesday, March 5, 2013. Egypt's Islamist president is considering whether to give the military full control of the restive Suez Canal city of Port Said after days of deadly street clashes stoked by excessive use of force by riot police, officials said Tuesday.(AP Photo)
Riot police clash with protesters in Port Said, Egypt, Tuesday, March 5, 2013. Egypt's Islamist president is considering whether to give the military full control of the restive Suez Canal city of Port Said after days of deadly street clashes stoked by excessive use of force by riot police, officials said Tuesday.(AP Photo)
Egyptians walk past a state security office burned during clashes in Port Said, Egypt, Tuesday, March 5, 2013. Egypt's Islamist president is considering whether to give the military full control of the restive Suez Canal city of Port Said after days of deadly street clashes stoked by excessive use of force by riot police, officials said Tuesday. (AP Photo)
CAIRO (AP) ? An Egyptian administrative court has ordered the suspension of parliamentary elections scheduled to begin next month, throwing the country's politics deeper into confusion.
The court says in its Wednesday ruling that the law organizing the elections must be reviewed by the Supreme Constitutional Court to determine its conformity to the constitution.
The ruling further snarls Egypt's political crisis over the divisions between Islamist President Mohammed Morsi and the mainly liberal and secular opposition. The opposition had called a boycott of the elections, saying they should not be held amid anti-Morsi protests and unrest that have shaken the country for weeks.
The multi-phase election is due to begin in late April and last for nearly two months.
The government can appeal the administrative court ruling.
MIAMI (Reuters) - A new book about immigration reform published on Tuesday by Jeb Bush is fueling speculation that the former Florida governor may be considering a run at the presidency in 2016.
In the book, Bush seizes the middle ground in a divisive political topic, proposing residency for undocumented immigrants but tough conditions for citizenship.
Bush's plan advocates against allowing undocumented immigrants to obtain citizenship unless they first return to their country of origin, according to the book "Immigration Wars: Forging an American Solution."
Asked by reporters on Tuesday if he is thinking of running in 2016, Bush did not discount the idea, in sharp contrast to his emphatic rejection of a run in the lead up to the 2012 Republican party presidential primaries.
NBC-TV political host Chuck Todd interviewed Bush on Tuesday and told viewers he was "seriously considering" entering the race. Hours later Bush told Reuters, "No, I told Chuck that's not accurate."
He added, "What I have seriously considered is not to consider it seriously for a while. It's so far away," he said.
Journalists were too obsessed with discussing future candidates, he added. "This is like crack cocaine for political reporters, bless their hearts," he said.
Bush's position on citizenship surprised some immigration advocates, as well as fellow Republicans, who had expected him to come out with more lenient proposals.
"I'm surprised and very disappointed," said Cheryl Little, director of Americans for Immigrant Justice, a Miami-based immigrant-advocacy group. "It was my impression that Governor Bush has long been a champion of fair and humane immigration reform."
Instead of citizenship, Bush, 60, argues that immigrants who came to the United States illegally could apply for permanent legal residency as long as they pay a fine and perform community service, and pay back taxes and learn English.
Under the Bush plan, undocumented immigrants would then be able to earn U.S. citizenship if they return to their home countries and apply through regular legal channels. They would also face a three- or 10-year bar depending on how long they had been in the United States illegally.
Bush makes an exception for young undocumented immigrants, known as DREAMers, who were brought to the United States by their parents before the age of 18. Under his plan, they would be given residency with the ability to apply for citizenship after five years.
Senate Majority Leader Harry Reid was quick to seize on the perception that Bush's stance on pathway to citizenship had hardened.
"Let's wait for a few minutes and see how Jeb Bush changes his mind again. His opinion on immigration is not evolving, it's devolving," he said.
CONTRASTING POSITIONS
Reid, the top Senate Democrat, contrasted Bush's position with that of Florida Republican Senator Marco Rubio, who has advocated giving immigrants a more direct pathway to citizenship without being forced to leave the United States, albeit also with strict conditions.
Speaking to reporters in Washington on Monday, Rubio said he had received a copy of the book last week from his longtime political mentor but had not had time to read it.
"I haven't had a chance to talk to him in depth on why he's adopted this new position," Rubio said.
Bush, who speaks Spanish and has been married to his Mexican-born wife for 38 years, has never previously endorsed a specific package of proposals on immigration reform, though he has on occasion sounded favorable to more generous terms for creating a pathway to citizenship.
Bush said his position has not changed, saying he has long believed in the "fundamental principle that coming to this country legally should be easier than coming illegally."
He said his book's proposals were not meant to be written in stone and were simply a set of recommendations. "There could be other ways to satisfy that principle, so long as it's clear in the law. If not you create a magnet for other people to come illegally," he said.
Bush cited a study published last month by the Pew Hispanic Center that found only 36 percent of Mexicans eligible for citizenship had availed themselves of that option. Mexican immigrants account for 6.1 million - about 55 percent - of the estimated 11.1 million in the United States as of 2011, it pointed out.
"So, based on past history, more than half of the people here illegally would be happy to come out of the shadows and get residency," he said.
Bush also takes a conservative stand in the book over family-based immigration, arguing that the number of relatives who are allowed to immigrate to be reunited with family members is too high.
Family-based immigration was a strain on the economy because many who are allowed entry are not of working age and "typically do not produce economic benefits," he writes.
"That's so un-American," said Little. "Family unity has long been a cornerstone of American immigration policy," she added.
(Additional reporting by Richard Cowan in Washington; Editing by Lisa Shumaker, Bernard Orr, Eric Walsh and Philip Barbara)
Ginger: I know that you are offering a free call for people to find out more about writing their book and about writing itself and about your upcoming class. ?Can you tell me who would benefit most from listening to the call?
?Lisa: Birth Your Book in 2013: 5 Keys to Write Your Bestseller At Last is for people who are writing nonfiction, particularly self-help, how-to or memoir, and who are either at the very beginning of the book-writing process or who started and got stuck and want to move ahead with more ease?and write the right book.
Ginger: What is special about your approach?
Lisa: A few things: One is the way I help people discover the book inside them. As you know, my signature exercise is what I call my ?Meet Your Muse? visualization. People often find they write a much better book because of the work we do in this exercise and we?ll cover a shortened version of this on the call on March 19.
Ginger: Great. What else?
Lisa: The creative aspect is one crucial part of it. As someone who?s won awards in marketing, I bring to the table the understanding of how to write a marketable book?that doesn?t mean writing a book that?s inauthentic in any way?it?s about writing a book that will more deeply resonate for your market?the specific people who are going to buy your book because of what they realize it can do for them. And it also means the book is more likely to be effective for them?and have the kind of impact an author wants to have on people and their lives.
Ginger: How do you teach that?
Lisa:. I have a system that can help people write a book rather quickly?even novices. You can have a first draft in as little as 8-12 weeks. And we?ll cover some of my tips on that initial teleseminar on March 19. It?s not about writing a cookie cutter type book and we don?t sacrifice quality for speed. It?s just that the approach is really systematic and it works!
Ginger: I can say from first-hand knowledge?you help people write high quality, marketable books and the track record to prove it. You have clients who are first time authors getting six figure book deals.
Lisa: That?s true and I try to bring that same kind of quality and marketability to authors who self publish, too.
Ginger: What might someone expect to learn from the call on March 19?
Lisa: We?ll cover some of those things that are critical to getting started and staying motivated and in action: motivation to prioritize the book, clarity about how they?ll make the time?and some fabulous tips on how to stick to it?because that?s where people often trip up.
We?ll also cover some of the critical questions that will help you shape your book concept.
And I?ll help people on the call connect with their own deep wisdom about the amazing book inside them.
I?ll share keys to writing a high quality, unique, marketable book quickly?and with ease.
Ginger: And I hope you?ll share the secrets that help your clients snag five and six figure book deals with top publishers!
Lisa: Of course!
Ginger: Realistically speaking, what can people expect from joining your award winning Bring Your Book to Life Program?I know lots of people think it?s completely impossible to write a book in 8 weeks?.
Lisa: I should start by saying that this model works really well for self-help and how-to books. Memoirs tend to take longer and I let people take the class a second time in the fall if they are writing memoir.
Ginger: Having taught the class for you last summer, I?d agree wholeheartedly about the types of books that work well. Also, I would also point out that the program is best for books that do not require extensive research.
Lisa: Yes, that?s true. I recommend leaving holes in the book for research?that can be done later if you know your subject well, but ,as you said, if you need to do lots of research for the book, it?s not the best fit.
Ginger: So, could you take readers through the process:
Lisa: As soon as someone signs up we start working on their book concept and the structure of their book. They get some fabulous materials?a workbook and CDs?to walk them through exercises that bring clarity and ease to the process?and fun, too. And then I work privately with them to refine the book concept?vision, goals, audience, features, content and structure.
Once they complete that pre-work, they can start working on the actual book. So that may be well before the April 23 class actually begins?because they?ll have all their course materials and access to me?or they can wait until class starts.
Generally, you?d write about a chapter or a bit more per week?and can have a first draft by the end of class. And that includes feedback on up to 30 pages of their writing and a customized editing plan from me. It takes some commitment and they get profound support every step of the way. Some people work on a book proposal in the class instead of a book, but most write a first draft of their book.
Ginger:?I had some of the best fun I?ve ever had as a teacher working with the class last summer.
Lisa: You know, I?d like to mention to that if readers are interested in working directly with you they can also request to work with you as their guide for the one-on-one work, since you?ve taught the class and I have sent you many clients.
Ginger: Where can people sign up for the call?
Lisa: Right here:
http://bit.ly/Mar19Call
?
Ginger: Thanks, Lisa.?I look forward to hearing the call on March 19!
JACKSON, Miss. (AP) ? The body of a slain Mississippi mayoral candidate was beaten and burned, a family member said Monday.
Marco McMillian's godfather, Carter Womack, said McMillian's family received the information from the Coahoma County coroner. Coroner Scotty Meredith declined to comment Monday, and a spokesman for the Coahoma County Sheriff's Department had no immediate comment.
But a person with direct knowledge of the investigation confirmed to The Associated Press that McMillian had some bruises and there were burns on at least one area of his body. The person wasn't authorized to publicly comment and spoke on condition of anonymity.
The cause of death has not been released. An autopsy was performed, but toxicology tests are pending, and authorities say it could take two weeks to get those results.
Womack said the coroner told family members that someone dragged McMillian's body under a fence and left it near a Mississippi River levee last week.
McMillian, 34, was a candidate for mayor of Clarksdale in the Mississippi Delta.
"We feel that this was not a random act of violence based on the condition of the body when it was found," said a statement released by his campaign.
The slaying received significant attention, in part, because McMillian's campaign said he was the first openly gay, viable candidate for public office in Mississippi.
Sheriff's deputies last week charged 22-year-old Lawrence Reed with murder in the case.
An investigation began Feb. 26 after McMillian's SUV slammed head-on into another vehicle on U.S. Highway 49 near the Coahoma and Tallahatchie county lines.
Reed was driving the car, but McMillian was not in it, authorities say. McMillian's body was found the next day.
Reed was treated for injuries at the Regional Medical Center in Memphis. The hospital said he was released Saturday.
Reed was being held without bond Monday pending extradition to Mississippi.
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Associated Press writer Adrian Sainz in Memphis, Tenn. Contributed to this report.
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